Journal: Malaria Journal

Article Title: Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds

doi: 10.1186/1475-2875-13-2

Figure Lengend Snippet: Cure rates in C57BL/6 wild-type (WT), CYP 2D knock-out, and humanized/CYP 2D6 knock-in mice 31 days post-inoculation with Plasmodium berghei in the absence or presence of NPC-1161B and tafenoquine

Article Snippet: Heads and thoraxes were triturated with a mortar and pestle and suspended in medium RPMI 1640 containing 1% C57BL/6 mouse serum (Rockland Co, Gilbertsville, PA, USA).

Techniques: Knock-Out, Knock-In

Journal: PLoS ONE

Article Title: Novel Cell and Tissue Acquisition System (CTAS): Microdissection of Live and Frozen Brain Tissues

doi: 10.1371/journal.pone.0041564

Figure Lengend Snippet: Representative images of subgranular layer of dentate gyrus collection from native adult rat brain tissue before ( A ), during ( B ) and after dissection ( C ). Tissue thickness = 300 µm, Scale bar = 250 µm; D. Phase contrast images of neurosphere colonies derived from E18 rat subventricular zone (SVZ). Partially differentiated ( E ) and undifferentiated (lower right inset) neurosphere (NS) colonies immunostained for nestin (green) and GFAP (red), the marker of neural progenitors and astrocytes, respectively. Scale bar = 100 µm.

Article Snippet: For this study, adult Wistar rats, adult FVB/N mice (6 to 9-months old) and embryonic (E18) C57 mouse brain tissues (BrainBits, LLC, IL) were used.

Techniques: Dissection, Derivative Assay, Marker